Santa Fe de la Vera Cruz, commonly shortened to Santa Fe, is the capital of the province of Santa Fe. Santa Fe contains the grave of Hernandarias, the first American-born governor in South America. Santa Fe is an important commercial and transportation center that services the surrounding rich agricultural lands.

Grain, vegetable oil, and meats are shipped by rail to Buenos Aires and Avellaneda for processing. A small tourist industry operates around the rural landscape, attracting urbanites to spend their holidays hunting and fishing. Despite the city's quiet nature, Santa Fe has been home to two constitutional conventions in the past fifteen years, and should Argentina take a dark turn, it may be home to a third.